RENUE BY SCIENCE NAD⁺ Defender is a unique combination of supplements formulated to reduce systemic inflammation to minimise NAD⁺ consumption, prevent cellular senescence, slow the rate of age-related DNA methylation, and increasing levels of NAMPT which is responsible for the conversion of nicotinamide to NAD⁺.

As you age, inflammation becomes the key consumer of NAD+ and levels drop. Decreasing systemic inflammation minimises NAD+ consumption, so it’s available for other purposes.

Each Capsule Contains:

• 110 mg Liposomal CaAKG
• 60 mg Liposomal Berberine
• 60 mg Liposomal Hyaluronic Acid (HLA)

About Defender

Defender is a unique combination of supplements formulated to reduce systemic inflammation.  Decreasing systemic inflammation will minimize NAD+ consumption so that it’s available for other purposes.

We combine Lipo Berberine, Lipo CaAKG, and Lipo HLA, which work together to help prevent cellular senescence and slow the rate of age-related DNA methylation, which can help to prevent some of the many “diseases of old age”.

Defender can also elevate levels of NAD+ by increasing an important enzyme responsible for the conversion of nicotinamide to NAD+, called NAMPT.  Defender is also formulated to promote new cartilage and bone, thereby reducing joint inflammation and pain.

• 60 capsules per bottle
• Liposomal CaAKG – 110 mg
• Liposomal Berberine – 60 mg
• Liposomal Hyaluronic Acid (HLA)- 60 mg
• cGMP Certified
• No artificial colours, flavours or preservatives. Non-GMO
• Suitable for vegans

About Liposomal Delivery

Renue By Science Lipo products are part of a sustained-released liposomal delivery system that provides superior absorption in easy-to-swallow capsules.

Renue By Science's process encapsulates and delivers their products intracellularly in their complete form where they can be absorbed and utilized rather than being destroyed in the stomach.

Lipo Berberine
Berberine is an alkaloid found in a variety of plants. It is similar to metformin in that it can help to regulate glucose and lipid metabolism.

Berberine Found to Increase NAD+ Levels, Lower Inflammation
In a study examining the effects of Berberine on NAD+ levels, it was found that Berberine increases an important enzyme responsible for the conversion of nicotinamide to NAD+, called NAMPT.

As we age, we accumulate senescent cells that secrete toxins which are inflammatory.  Berberine is one of the most promising interventions to slow the accumulation of senescent cells and the inflammation they secrete by inducing autophagy, the body’s way of clearing out dead and damaged cells to make way for new ones.

Berberine’s benefits extend beyond the induction of autophagy and include optimizing metabolic pathways and upregulating the molecules that maintain the epigenome. It has also been shown to increase NAD+ levels through its activation of the AMPK enzyme.

Research also indicates there is an important synergy between two ingredients, berberine and CaAKG.  AMPK is upregulated by berberine and AMPK upregulates isocitrate dehydrogenase in the Krebs cycle, which produces alpha-ketoglutarate (AKG).

LIPO Berberine offers advanced support for:

• Metabolic function and clearing senescent cells
• Weight Management
• AMPK activation
• Blood sugar and insulin metabolism
• Microbiome balance

Lipo CaAKG
Calcium-alpha-ketoglutarate (CaAKG for short) is a special form of mineral calcium used to restore calcium concentration levels in the blood back to normal.

CaAKG Slows Effects of Aging and Reduces Inflammation
CaAKG works by slowing the rate of age-related DNA methylation and reducing the inflammation caused by senescent cells: two proposed reasons why we age.

CaAKG also contributes to metabolism, providing energy for cellular processes. It helps stimulate collagen and protein synthesis and influences age-related processes including stem cell proliferation. Increasing Calcium Alpha-Ketoglutarate in the body supports your liver and its detoxification abilities.

LIPO CaAKG offers advanced support for:

• Restoring and maintaining DNA integrity
• Athletic performance and recovery
• Managing age-related inflammation
• Oxidative stress
• Cellular Detoxification

Lipo HLA
Hyaluronic Acid is a polysaccharide molecule, one of the main components in connective tissue and which forms a gelatinous matrix that surrounds cells.

HLA Promotes New Cell Growth and Reduces Inflammation
Hyaluronic acid (HLA) is important for promoting the growth of new cells and tissues in the joint’s cartilage and bone, thereby reducing joint inflammation and pain caused by injuries or tissue degeneration.

HLA is also a key molecule involved in skin hydration.  The natural production of Hyaluronic Acid rapidly declines by up to 50% by the time we’re 50 years old. Studies show that consuming extra hyaluronic acid boosts the body’s natural production of collagen.

LIPO HLA offers advanced support for:

• Restoring youthful skin
• Reducing joint pain and inflammation
• Healthy digestion
• Preserving bone mass

Suggested Use: For best results, take one (1) capsule daily as a dietary supplement.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a doctor before using.

Store in a cool, dry place.